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Molecule Parameter List for eIF4E-BP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*eIF4E-BP* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
4EBP	89	Network	Shared_Object_4EBP, mTOR_model, 4E-BP_mod
Rheb-GTP activates mTOR, again with regulation by MAPK, leading to formation of the eIF4F-mRNA complex.

eIF4E-BP acting as a Molecule in 4EBP Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
eIF4E-BP	4EBP Accession No. : 89	4E-BP_mod Pathway No. : 1092	0.2	1000	No

eIF4E-BP acting as a Substrate for an Enzyme in 4EBP Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
TOR_Rheb-GTP_ clx / TOR_4E-BP_ phospho	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	1.80001	1	4	explicit E-S complex	Substrate eIF4E-BP Product eIF4E-BP_thr37_ 46

eIF4E-BP acting as a Product of an Enzyme in 4EBP Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP2A / PP2A_4EBP	4EBP Accession No. : 89	Shared_Object_ 4EBP Pathway No. : 1090	8.80028	1	4	explicit E-S complex	Substrate eIF4E-BP_thr37_ 46 Product eIF4E-BP

eIF4E-BP acting as a Product in a reaction in 4EBP Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
eIF4E_bind_BP2	4EBP Accession No. : 89	4E-BP_mod Pathway No. : 1092	49.999 (uM^-1 s^-1)	0.15 (s^-1)	Kd(bf) = 0.003(uM)	-	Substrate 4E-BP eIF4E Product eIF4E-BP

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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