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Molecule Parameter List for inhibited-PKA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
inhibited-PKA participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
cAMP_pathway25Network
Shared_Object_cAMP_pathway PKA AC 
Gs 
This is a model of the canonical cAMP signaling pathway:
Ligand->Receptor->G-protein->Cyclase->cAMP->PKA.
It also includes phosphodiesterases to balance out cAMP formation.Bhalla US Methods Enzymol. 2002;345:3-23

inhibited-PKA acting as a Molecule in  
cAMP_pathway Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
inhibited-PKAcAMP_pathway
Accession No. : 25
PKA
Pathway No. : 135
01000No

inhibited-PKA acting as a Product in a reaction in  
cAMP_pathway Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
inhib-PKAcAMP_pathway
Accession No. : 25
PKA
Pathway No. : 135
60
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.0167(uM)-Substrate
PKA-active
PKA-inhibitor

Product
inhibited-PKA
This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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