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Molecule List for Accession NOS_Phosph_regulation (Accession Number20) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
  arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| |
Name | Pathway Name /
Pathway No. | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | Ca-CaMnNOS | NOS
Pathway No. 90 | Pathway | 0 | 0.0016667 | No | - | | 2 | CaM-Ca4 | NOS
Pathway No. 90 | Pathway | 20 | 0.0016667 | Yes | - | | 3 | CaMKIalpha | NOS
Pathway No. 90 | Pathway | 1 | 0.0016667 | Yes | - | | | Phosphorylates nNOS, but not as effective as CaMKIIalpha. (Hayashi et al., 1999,JBC,274(29):20597-20602.) Report of Plateau Level in their phosphorylation plots reaching after 100 min. -- ~0.4 mol of 32p/mol of nNOS. | | 4 | CaMKIIalpha | NOS
Pathway No. 90 | Pathway | 1 | 0.0016667 | Yes | - | | | CaMKIIalpha caused the most rapid phosphorylation of nNOS, with half-maximal phosphorylation apparent at 3 min and plateau level at 10 min. (Hayashi et al., 1999,JBC,274(29):20597-20602). The Maximal Phosphorylation of nNOS was observed at ~0.4 mol of 32p/mol of nNOS under their expt conditions. | | 5 | CaMKIV | NOS
Pathway No. 90 | Pathway | 1 | 0.0016667 | Yes | - | | | Activity is similar to CaMKIalpha, with ~0.7 mol of 32p/mol of nNOS. (Hayashi et al., 1999,JBC,274(29):20597-20602) | | 6 | cit | NOS
Pathway No. 90 | Pathway | 0 | 0.0016667 | No | - | | 7 | Larg | NOS
Pathway No. 90 | Pathway | 100 | 0.0016667 | No | - | | 8 | nNOS | NOS
Pathway No. 90 | Pathway | 0.5 | 0.0016667 | No | - | | | neuronal Nitric Oxide Synthase. Found in the neurons, activity is dependent on CaM binding, in response to Ca levels. Molecular weight ~160 kDa. This is unphosporylated form of nNOS. | | 9 | NO | NOS
Pathway No. 90 | Pathway | 0 | 0.0016667 | No | - | | 10 | NOS* | NOS
Pathway No. 90 | Pathway | 0 | 0.0016667 | No | - | | | Phosporylated NOS, by CaM kinases, with lowering of Vmax, but little change in Km for Arg and Kact for CaM. (Hayashi et al., JBC, 1999, 274(29):20597-20602) |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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