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Molecule List for pathway PKA (Pathway Number 30) in Accession fig4_synapse (Accession Number 3)
| Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.|
arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using and color.
|Buffered||Sum Total Of|
|1|| inhibited-PKA||Network||0||0||No||- |
|2|| PKA-inhibitor||Network||0.25||0||No||- |
|3|| R2-cAMP4||Network||0||0||No||- |
|4|| R2C-cAMP4||Network||0||0||No||- |
| || R-dimer bound to 4 cAMP molecules.|
|5|| R2C2||Network||0.5||0||No||- |
| || PKA: Protein kinase activated by cAMP.|
R2C2 complex consists of 2 catalytic (C) subunits, and the R-dimer. There are two types of cAMP binding sites termed A and B according to the rate with which they exchange bound labelled nucleotide.
Dagfinn Ogreid and Stein Ove Doskeland (1981) Int.J.Biochem. 13(1):1-19
Physiological concentration of PKA = 0.59 uM (cardiac myocyte)
Jeffrey J. Saucerman et al (2003) J.Biol.Chem. 278(48):47997-48003
|6|| R2C2-cAMP||Network||0||0||No||- |
| || R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to site B1 on the regulatory subunit.|
|7|| R2C2-cAMP2||Network||0||0||No||- |
| || R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to each of the B sites on the regulatory subunit.|
|8|| R2C2-cAMP3||Network||0||0||No||- |
| || R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 3 cAMP molecules bound to it.|
|9|| R2C2-cAMP4||Network||0||0||No||- |
| || R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 4 cAMP molecules bound to it. All the regulatory subunits now have cAMP bound. This state is ready to dissociate and to release the catalytic subunit.|
|Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR |
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