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Molecule List for pathway PP1 (Pathway Number 341) in Accession Ajay_Bhalla_2004_PKM_MKP3_Tuning (Accession Number 77)
| Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.|
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The entries are grouped according to Pathway Number and are alternately color coded using and color.
|Buffered||Sum Total Of|
|1|| I1||Network||1.8||1.5||No||- |
| || I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183). We treat it as non-compet, so it just turns the enz off without interacting with the binding site. Cohen et al ann rev bioch refer to results where conc is 1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM, we need >= 1.8 uM. |
|2|| I1*||Network||0.001||1.5||No||- |
| || Dephosph is mainly by PP2B |
|3|| PP1-I1||Network||0||1.5||No||- |
|4|| PP1-I1*||Network||0||1.5||No||- |
|Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR |
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