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Molecule List for pathway Gq (Pathway Number 351) in Accession Ajay_Bhalla_2004_Feedback_Tuning (Accession Number 78) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering. arrow indicates that ordering is done according to ascending or descending order. The entries are grouped according to Pathway Number and are alternately color coded using and color. |
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Name | Accession Type | Initial Conc. (uM) | Volume (fL) | Buffered | Sum Total Of | 1 | Blocked-rec-Gq | Network | 0 | 0 | No | - | 2 | G-GDP | Network | 1 | 0 | No | - | | From M&L, total Gprot = 1e5molecules/cell At equil, 92340 are here, 400 are in G*GTP, and another 600 are assoc with the PLC and 6475 are as G*GDP. This is OK. From Pang and Sternweis JBC 265:30 18707-12 1990 we get conc est 1.6 uM to 0.8 uM. A number of other factors are involved too. | 3 | mGluR | Network | 0.3 | 0 | No | - | | From M&L, Total # of receptors/cell = 1900 Vol of cell = 1e-15 (10 um cube). Navogadro = 6.023e23 so conversion from n to conc in uM is n/vol*nA * 1e3 = 1.66e-6 However, for typical synaptic channels the density is likely to be very high at the synapse. Use an estimate of 0.1 uM for now. this gives a total of about 60K receptors/cell, which is in line with Fay et at. | 4 | mGluRAntag | Network | 0 | 0 | Yes | - | | I am implementing this as acting only on the Rec-Gq complex, based on a more complete model PLC_Gq48.g which showed that the binding to the rec alone contributed only a small amount. | 5 | Rec-Glu | Network | 0 | 0 | No | - | | This acts like an enzyme to activate the g proteins Assume cell has vol 1e-15 m^3 (10 uM cube), conversion factor to conc in uM is 6e5 | 6 | Rec-Glu-Gq | Network | 0 | 0 | No | - | 7 | Rec-Gq | Network | 0 | 0 | No | - | | Fraction of Rec-Gq is 44% of rec, from Fay et al. Since this is not the same receptor, this value is a bit doubtful. Still, we adjust the rate consts in Rec-bind-Gq to match. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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