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Molecule List for pathway Sos (Pathway Number 78) in Accession Synaptic_Network (Accession Number 16)

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The entries are grouped according to Pathway Number and are alternately color coded using  and  color.

BufferedSum Total Of
1 Grb2Network10No
    There is probably a lot of it in the cell: it is also known as Ash (abundant src homology protein). Also Waters et al JBC 271:30 18224 1996 say that only a small fraction of cellular Grb is precipitated out when SoS is precipitated. As most of the Sos seems to be associated with Grb2, it would seem like there is a lot of the latter. Say 1 uM. This would comfortably saturate the SoS.
2 SosNetwork0.10No
    I have tried using low (0.02 uM) initial concs, but these give a very flat response to EGF stim although the overall activation of Ras is not too bad. I am reverting to 0.1 because we expect a sharp initial response, followed by a decline.
3 Sos*Network00No
    Phosphorylated form of SoS. Nominally this is an inactivation step mediated by MAPK, see Profiri and McCormick 1996 JBC 271(10):5871. I have not put this inactivation in this pathway so this molecule currently only represents a potential interaction point.
4 Sos*.Grb2Network00No
    Inactive complex of Sos* with Grb2 due to phosphorylation of the Sos. See Porfiri and McCormick 1996 JBC 271(10):5871.
5 Sos.Grb2Network00No
    For simplicity I treat the activation of Sos as involving a single complex comprising Sos, Grb2 and Shc*. This is reasonably documented: Sasaoka et al 1994 JBC 269(51):32621-5 Chook et al JBC 1996 271(48):30472

Result: 1 - 5 of 5 rows are displayed

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