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Result: 1 - 3 of 3 rows are displayed

Reaction List for pathway Ras (Pathway Number 63) in Accession MAPK_MKP1_oscillation (Accession Number 9)

Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.  indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
  Reaction
Name
Pathway Name / 
Pathway No.
KfKbKdtauReagents
1 dephosph-GEFRas

Pathway No. 63
1
(s^-1)
0
(s^-1)
--  Substrate:
 GEF*

 Products:
 inact-GEF
2 
  • Ras-intrinsic-GT
    Pase
  • Ras

    Pathway No. 63
    0.0001
    (s^-1)
    0
    (s^-1)
    --  Substrate:
     GTP-Ras

     Products:
     GDP-Ras
      This is extremely slow (1e-4), but it is significant as so little GAP actually gets complexed with it that the total GTP turnover rises only by 2-3 X (see Gibbs et al, JBC 265(33) 20437-20422) and Eccleston et al JBC 268(36) 27012-27019 kf = 1e-4
    3 dephosph-GAPRas

    Pathway No. 63
    0.1
    (s^-1)
    0
    (s^-1)
    --  Substrate:
     GAP*

     Products:
     GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec

     
    Result: 1 - 3 of 3 rows are displayed



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