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Accession Type:
Network

CaMKIV_submodel

		Shared Object_ CaMKIV_submodel
		Molecule
		Enzyme
		Reaction

compartment_1compartment_1

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Molecule List for pathway Shared Object_CaMKIV_submodel (Pathway Number 1110)

	Name	Initial Conc. (uM)	Volume (fL)	Buffered
1	Ca	0.08	1000	Yes

2	CaM	10	1000	No
	There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
3	CaMKIVc	5.7	1000	No

4	CaMKIVdephos_cplx	0	1000	No

5	CaMKIVphosph_cplx	0	1000	No

6	CaMKIV_CaM_Ca_c	0	1000	No

7	CaMKKdephosph_cplx	0	1000	No

8	CaMKKp	0	1000	No

9	CaMKKphosph_cplx	0	1000	No

10	CaMKK_c	100000	1000	No
	Concentration calculated from PMID: 7883770
11	CaMKK_CaM_Ca_c	0	1000	No

12	CaM_dash_Ca	0	1000	No
	This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
13	CaM_dash_Ca2	0	1000	No
	This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
14	CaM_dash_Ca3	0	1000	No

15	CaM_dash_Ca4	0	1000	No

16	pCaMKIV_CaM_Ca_c	0	1000	No

17	PKA_dash_active	0.0076	1000	Yes

18	PP2Ac	0.15	1000	Yes
	Concentration from DOQCS accession no. 90

Pathway Details Molecule List Enzyme List Reaction List

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