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Accession Type:
Network
NonOsc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
IP3-3K
 Molecule
 Enzyme
 Reaction
CaRegulation
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos

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Molecule List for pathway IP3-3K (Pathway Number 148)

 Name Initial Conc. (uM) Volume (fL) Buffered
13kCaM*_ip3_cmplx01000No
    Enzyme complex exclusively modeled as M-M kinetics do not hold. Enzyme is reversible as per free energy calculations that yield a a significant back flux.
23kCaM_ip3_cmplx01000No
    Enzyme complex exclusively modeled because enzymes is reversible, unlike M-M enzymes. Reversibility determined from dG calculations.
3IP3(145)0.21000No
    Inositol (145)trisphosphate
4IP3_3K0.38531000No
    from Johanson et al, JBC, 1988, Vol. 263, No.16, pp 7465-7471 this is the predominant isoform in brain ie IP3-3kinaseA: BiochemJ, 1995, 306, 429-435
5IP3_3K*01000No
    phosphorylation at thr311 Communi et al, EMBO J 16; 1997
6IP3_3K*101000No
    Sim et al; JBC 265(18) June 25; 1990: pp 10367-10372 Phos. at 2 major sites = Ser109 & Ser 175; but there is a possibility that inactivation is due to combined effect of multiple phosphorylations activity suppressed by 75%
7IP3_3K_CaM01000No
    2-2.5 fold increase in enzyme activity due to CaM binding CaM binding involves Trp165 Erneux et al; Biochem 214, 497-501 (1993)
8IP3_3K_CaM*01000No
    8-10 fold activation with both CaM bound and CaMKII phosphorylation (phos at thr311) Communi et al; EMBO J 16 (8), pp 1943-1952, 1997
9IP4(1345)11000No
    Inositol(1345)tetrakisphosphate


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