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Reaction List for pathway TetR (Pathway Number 299) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
TetR_
degradation | kf
(s^-1) | 0
(s^-1) | - | - | TetR-1
| Degraded_TetR
| | | This reaction denotes the degradation of TetR, kf is chosen from a random gaussian distribution. Ref: Fig 2 Garcia and Elowitz et al. (2004) PNAS 101(30) 10955 - 60 | | 2 |
tetR_mRNA_
degradation | kf
(s^-1) | 0
(s^-1) | - | - | tetR_mRNA1
| Degraded_tetR_
mRNA
| | | This reaction denotes the degradation of the tetR m-RNA, the half life of which is two minutes. t1/2 = 0.693/k where k denotes kf Elowitz, M. et al. (2000) Nature 403:335-338 | | 3 |
TetR_operator_
inhibition_
reaction | kf
(uM^-1 s^-1) | 224
(s^-1) | Kd(bf) = 0.224(uM) | - | TetR_operator
Lac-1
| TetR_operator_
1st_bound
| | | It signifies the first binding of the repressor with the operator Kf = 1 /nM/sec Kb = 224 /sec Box 1 Elowitz, M. et al. (2000) Nature 403:335-338 | | 4 |
TetR_operator_
inhibition_
reaction[1] | kf
(uM^-1 s^-1) | 9
(s^-1) | Kd(bf) = 0.009(uM) | - | TetR_operator_
1st_bound
Lac-1
| TetR_operator_
2nd_bound
| | | It signifies the second binding of the repressor with the operator Kf = 1 /nM/sec Kb = 9 /sec Box 1 Elowitz, M. et al. (2000) Nature 403:335-338 |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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