|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule Parameter List for NO_sGCpart_act | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | CondorelliGC | 19 | Pathway |
condorelliGCmod | | This model features the observations of Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9. They propose a in vivo mechanism for the binding of free NO to sGC based on in vitro data within both pulmonary and vascular smooth muscle. All the parameters used have been obtained from reported results based on experiments. One important conclusion they make is that control of sGC in vivo is most likely to be ultra-sensitive and that activation in vivo occurs at lower NO concentrations than previously reported. |
NO_sGCpart_act acting as a Molecule in CondorelliGC Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | NO_sGCpart_act | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 0 | 0.0016667 | No | | This is the partiallly active form of sGC bound with NO, as proposed by Condorelli et al., 2001, Biophys J, 80:2110-2119.. based originally on Zhao et al., 1999, PNAS,96:14753-14758. |
NO_sGCpart_act acting as a Substrate in a reaction in CondorelliGC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | NOdepPway | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 1.68
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
NO_a
NO_sGCpart_act
Product
NO_sGCfull_act
| | | Rates from stopped flow experiments performed at 4C from Zhao et al., 1999, PNAS,96:14753-14758. Same rates used by Condorelli P, for his simulations... | | 2 | NOindePway | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 0.0609
(s^-1) | 0.014
(s^-1) | Keq = 0.2299(uM) | 13.351sec | Substrate
NO_sGCpart_act
Product
NO_sGCfull_act
| | | Rates used directly from Condorelli et al., 2001, Biophysical J, 80:2110-2119 .... Rates originally from Zhao et al., 1999, PNAS, 96:14753-14758 from stopped flow spectroscopy experiments performed at 4C. |
NO_sGCpart_act acting as a Product in a reaction in CondorelliGC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | NObind_sGC | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 980
(uM^-1 s^-1) | 350
(s^-1) | Kd(bf) = 0.3571(uM) | - | Substrate
NO
sGC_basal
Product
NO_sGCpart_act
| | Rates at 4C... used directly from paper by Condorelli P, 2001, Biophysical J, 80:2110-2119, which in turn have been obtained mainly from Zhao et al., 1999, PNAS,96:14753-14758. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
