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Molecule Parameter List for NO_sGCpart_act

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

NO_sGCpart_act participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	2	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CondorelliGC	19	Pathway	condorelliGCmod
This model features the observations of Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9. They propose a in vivo mechanism for the binding of free NO to sGC based on in vitro data within both pulmonary and vascular smooth muscle. All the parameters used have been obtained from reported results based on experiments. One important conclusion they make is that control of sGC in vivo is most likely to be ultra-sensitive and that activation in vivo occurs at lower NO concentrations than previously reported.

NO_sGCpart_act acting as a Molecule in  CondorelliGC Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
NO_sGCpart_act	CondorelliGC Accession No. : 19	condorelliGCmod Pathway No. : 89	0	0.0016667	No
This is the partiallly active form of sGC bound with NO, as proposed by Condorelli et al., 2001, Biophys J, 80:2110-2119.. based originally on Zhao et al., 1999, PNAS,96:14753-14758.

NO_sGCpart_act acting as a Substrate in a reaction in  CondorelliGC Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	NOdepPway	CondorelliGC Accession No. : 19	condorelliGCmod Pathway No. : 89	1.68 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate NO_a NO_sGCpart_act Product NO_sGCfull_act
	Rates from stopped flow experiments performed at 4C from Zhao et al., 1999, PNAS,96:14753-14758. Same rates used by Condorelli P, for his simulations...
2	NOindePway	CondorelliGC Accession No. : 19	condorelliGCmod Pathway No. : 89	0.0609 (s^-1)	0.014 (s^-1)	Keq = 0.2299(uM)	13.351sec	Substrate NO_sGCpart_act Product NO_sGCfull_act
	Rates used directly from Condorelli et al., 2001, Biophysical J, 80:2110-2119 .... Rates originally from Zhao et al., 1999, PNAS, 96:14753-14758 from stopped flow spectroscopy experiments performed at 4C.

NO_sGCpart_act acting as a Product in a reaction in  CondorelliGC Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
NObind_sGC	CondorelliGC Accession No. : 19	condorelliGCmod Pathway No. : 89	980 (uM^-1 s^-1)	350 (s^-1)	Kd(bf) = 0.3571(uM)	-	Substrate NO sGC_basal Product NO_sGCpart_act
Rates at 4C... used directly from paper by Condorelli P, 2001, Biophysical J, 80:2110-2119, which in turn have been obtained mainly from Zhao et al., 1999, PNAS,96:14753-14758.