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Molecule Parameter List for sGC_basal | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | CondorelliGC | 19 | Pathway |
condorelliGCmod | | This model features the observations of Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9. They propose a in vivo mechanism for the binding of free NO to sGC based on in vitro data within both pulmonary and vascular smooth muscle. All the parameters used have been obtained from reported results based on experiments. One important conclusion they make is that control of sGC in vivo is most likely to be ultra-sensitive and that activation in vivo occurs at lower NO concentrations than previously reported. |
sGC_basal acting as a Molecule in CondorelliGC Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | sGC_basal | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 3 | 0.0016667 | No | | Intracellular levels of sGC is around 3 uM, as sGC is enriched in Purkinje cells. (Shinya Kuroda, personal correpondence)... |
sGC_basal acting as a Substrate in a reaction in CondorelliGC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | NObind_sGC | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 980
(uM^-1 s^-1) | 350
(s^-1) | Kd(bf) = 0.3571(uM) | - | Substrate
NO
sGC_basal
Product
NO_sGCpart_act
| | Rates at 4C... used directly from paper by Condorelli P, 2001, Biophysical J, 80:2110-2119, which in turn have been obtained mainly from Zhao et al., 1999, PNAS,96:14753-14758. |
sGC_basal acting as a Product in a reaction in CondorelliGC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | dissoNO | CondorelliGC
Accession No. : 19 | condorelliGCmod
Pathway No. : 89 | 0.07
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
NO_sGCfull_act
Product
NO
sGC_basal
| | This is a modification by Condorelli et al., 2001, Biophys J of the recent binding scheme of Zhao et al., to include the NO dissociation from fully active complex of sGC... The dissociation is characterised by the respective first order rate constants depicted in the model... Rates are obtained at 4C... |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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