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Molecule Parameter List for PKA-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKA-active participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020012

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII,  CaMKII,  CaM,  
PP1,  PP2B,  PKA,  
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

PKA-active acting as a Molecule in  fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
PKA-activefig3_CaMKII
Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 01000No

    PKA-active acting as an Enzyme in      fig3_CaMKII Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKA-active /
    PKA-phosph-I1
    		fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 7.594explicit E-S complexSubstrate
    I1

    Product
    I1*
    2PKA-active /
    phosph-PDE
    		fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 7.594explicit E-S complexSubstrate
    cAMP-PDE

    Product
    cAMP-PDE*

    PKA-active acting as a Substrate in a reaction in      fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    inhib-PKAfig3_CaMKII
    Accession No. : 2    		PKA
    Pathway No. : 17    		60
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    PKA-active
    PKA-inhibitor

    Product
    inhibited-PKA

    PKA-active acting as a Product in a reaction in      fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Release-C1fig3_CaMKII
    Accession No. : 2    		PKA
    Pathway No. : 17    		60
    (s^-1)    		18
    (uM^-1 s^-1)    		Kd(cb) = 0.3(uM)-Substrate
    R2C2-cAMP4

    Product
    PKA-active
    R2C-cAMP4
      The complex starts to dissociate and release catalytic subunit C. This has to be fast, as the activation of PKA by cAMP is also fast.
    2Release-C2fig3_CaMKII
    Accession No. : 2    		PKA
    Pathway No. : 17    		60
    (s^-1)    		18
    (uM^-1 s^-1)    		Kd(cb) = 0.3(uM)-Substrate
    R2C-cAMP4

    Product
    PKA-active
    R2-cAMP4


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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