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Molecule Parameter List for R2-cAMP4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
R2-cAMP4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

R2-cAMP4 acting as a Molecule in  
fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
R2-cAMP4fig3_CaMKII
Accession No. : 2
PKA
Pathway No. : 17
01000No
R-dimer is bound to 4 cAMP molecules.

R2-cAMP4 acting as a Product in a reaction in  
fig3_CaMKII Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Release-C2fig3_CaMKII
Accession No. : 2
PKA
Pathway No. : 17
60
(s^-1)
18
(uM^-1 s^-1)
Kd(cb) = 0.3(uM)-Substrate
R2C-cAMP4

Product
PKA-active
R2-cAMP4



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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