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Molecule Parameter List for CaMKII-thr286*-CaM

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-thr286*-CaM participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1101201

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII,  CaMKII,  CaM,  
PP1,  PP2B,  PKA,  
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

CaMKII-thr286*-CaM acting as a Molecule in  fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
CaMKII-thr286*-CaMfig3_CaMKII
Accession No. : 2		CaMKII
Pathway No. : 13		01000No

CaMKII-thr286*-CaM acting as a Summed Molecule in  fig3_CaMKII Network
Accession NamePathway NameTargetInput
fig3_CaMKII
Accession No. : 2		CaMKII
Pathway No. : 13		tot_CaM_CaMKIICaMKII-CaM
  • CaMKII-thr286*-C
    aM

    • CaMKII-thr286*-CaM acting as a Substrate for an Enzyme in      fig3_CaMKII Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr286    		fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 5.099070.354explicit E-S complexSubstrate
  • CaMKII-thr286*-C
    aM

    Product
    CaMKII-CaM

    • CaMKII-thr286*-CaM acting as a Product of an Enzyme in      fig3_CaMKII Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1tot_CaM_CaMKII  /
    CaM_act_286    		fig3_CaMKII
    Accession No. : 2    		CaMKII
    Pathway No. : 13    		0.000002705630.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM
    • 2
  • tot_autonomous_
    CaMKII      /
    auton_286
    		• fig3_CaMKII
    Accession No. : 2    		CaMKII
    Pathway No. : 13    		0.000004166670.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM

    • CaMKII-thr286*-CaM acting as a Product in a reaction in      fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • CaMK-thr286-bind
    -CaM
    		• fig3_CaMKII
    Accession No. : 2    		CaMKII
    Pathway No. : 13    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-Substrate
    CaM-Ca4
    CaMKII-thr286

    Product
  • CaMKII-thr286*-C
    aM


    • Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.