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Molecule Parameter List for CaM-Ca4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM-Ca4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000051

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII,  CaMKII,  CaM,  
PP1,  PP2B,  PKA,  
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

CaM-Ca4 acting as a Molecule in  fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
CaM-Ca4fig3_CaMKII
Accession No. : 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. : 12
    		• 01000No

    CaM-Ca4 acting as a Substrate in a reaction in      fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1CaMKII-bind-CaMfig3_CaMKII
    Accession No. : 2    		CaMKII
    Pathway No. : 13    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-Substrate
    CaM-Ca4
    CaMKII

    Product
    CaMKII-CaM
    2
  • CaMK-thr286-bind
    -CaM
    		• fig3_CaMKII
    Accession No. : 2    		CaMKII
    Pathway No. : 13    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-Substrate
    CaM-Ca4
    CaMKII-thr286

    Product
  • CaMKII-thr286*-C
    aM
    • 3CaM-bind-AC1fig3_CaMKII
    Accession No. : 2    		AC
    Pathway No. : 18    		49.9998
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.02(uM)-Substrate
    AC1
    CaM-Ca4

    Product
    AC1-CaM
    4
  • CaMCa4-bind-CaNA
    B
    		• fig3_CaMKII
    Accession No. : 2    		PP2B
    Pathway No. : 16    		600
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.0017(uM)-Substrate
    CaM-Ca4
    CaNAB-Ca4

    Product
    CaMCa4-CaNAB
    5CaM_bind_PDE1fig3_CaMKII
    Accession No. : 2    		AC
    Pathway No. : 18    		720
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.0069(uM)-Substrate
    CaM-Ca4
    PDE1

    Product
    CaM.PDE1

    CaM-Ca4 acting as a Product in a reaction in      fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaM-Ca3-bind-Cafig3_CaMKII
    Accession No. : 2    		CaM
    Pathway No. : 14    		0.465
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 21.5054(uM)-Substrate
    Ca
    CaM-Ca3

    Product
    CaM-Ca4


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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