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Molecule Parameter List for CaNAB-Ca4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaNAB-Ca4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1110031

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig3_CaMKII2Network
Shared_Object_fig3_CaMKII CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.

CaNAB-Ca4 acting as a Molecule in  
fig3_CaMKII Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
CaNAB-Ca4fig3_CaMKII
Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • 01000No

    CaNAB-Ca4 acting as a Summed Molecule in  
    fig3_CaMKII Network
    Accession NamePathway NameTargetInput
    fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • tot_CaN-activeCaM(Ca)n-CaNAB
    CaNAB-Ca4

    CaNAB-Ca4 acting as an Enzyme in  
    fig3_CaMKII Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    CaNAB-Ca4 /
  • dephosph_
    inhib1_noCaM
  • fig3_CaMKII
    Accession No. : 2
  • Shared_Object_
    fig3_CaMKII

    Pathway No. : 12
  • 4.970760.0344explicit E-S complexSubstrate
    I1*

    Product
    I1

    CaNAB-Ca4 acting as a Substrate in a reaction in  
    fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • CaM-Ca2-bind-CaN
    AB
  • fig3_CaMKII
    Accession No. : 2
    PP2B
    Pathway No. : 16
    0.24
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 4.1667(uM)-Substrate
    CaM-TR2-Ca2
    CaNAB-Ca4

    Product
    CaMCa2-CANAB
    2
  • CaMCa3-bind-CaNA
    B
  • fig3_CaMKII
    Accession No. : 2
    PP2B
    Pathway No. : 16
    2.238
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.4468(uM)-Substrate
    CaM-Ca3
    CaNAB-Ca4

    Product
    CaMCa3-CaNAB
    3
  • CaMCa4-bind-CaNA
    B
  • fig3_CaMKII
    Accession No. : 2
    PP2B
    Pathway No. : 16
    600
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.0017(uM)-Substrate
    CaM-Ca4
    CaNAB-Ca4

    Product
    CaMCa4-CaNAB

    CaNAB-Ca4 acting as a Product in a reaction in  
    fig3_CaMKII Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • Ca-bind-CaNAB-Ca
    2
  • fig3_CaMKII
    Accession No. : 2
    PP2B
    Pathway No. : 16
    3.6
    (uM^-2 s^-1)
    1
    (s^-1)
    Kd(af) = 0.527(uM)-Substrate
    Ca
    Ca
    CaNAB-Ca2

    Product
    CaNAB-Ca4



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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