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Molecule Parameter List for CaMKIIalpha | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| CaMKIIalpha participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | NOS_Phosph_
regulation | 20 | Pathway |
NOS | | This model features the phosphorylation of rat brain neuronal NOS expressed in E. coli or Sf9 cells, which leads to a decrease in Vmax of the phosphorylated enzyme, with little change of both the Km for L-arginine and Kact for CaM. This is based on Hayashi Y. et al. J Biol Chem. (1999) 274(29):20597-602. They report of phosphorylatin being carried out by CaM kinases I alpha, II alpha and IV. The rates used have been obtained from their paper and from other reported experimental data. |
CaMKIIalpha acting as a Molecule in NOS_Phosph_regulation Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | CaMKIIalpha | NOS_Phosph_
regulation
Accession No. : 20 | NOS
Pathway No. : 90 | 1 | 0.0016667 | Yes | | CaMKIIalpha caused the most rapid phosphorylation of nNOS, with half-maximal phosphorylation apparent at 3 min and plateau level at 10 min. (Hayashi et al., 1999,JBC,274(29):20597-20602). The Maximal Phosphorylation of nNOS was observed at ~0.4 mol of 32p/mol of nNOS under their expt conditions. |
CaMKIIalpha acting as an Enzyme in NOS_Phosph_regulation Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | CaMKIIalpha /
kenz
| NOS_Phosph_
regulation
Accession No. : 20 | NOS
Pathway No. : 90 | 5 | 28.5 | 4 | explicit E-S complex | Substrate
nNOS
Product
NOS*
| | Hayashi et al., 1999, JBC,274(29):20597-20602. and from various other literature datas. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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