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Reaction List for Accession NOS_Phosph_regulation (Accession Number 20) | Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.   indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules] |
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Reaction
Name | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents | | 1 | Ca-CaMbind_nNOS | NOS
Pathway No. 90 | 3.25
(uM^-1 s^-1) | 0.05
(s^-1) | Kd(bf) = 0.0154(uM) | - | Substrate:
nNOS
CaM-Ca4
Products:
Ca-CaMnNOS
| | Those binding CaM have a high Kd, including nNOS, ~<=10nM. The binding of CaM to nNOS has been demonstrated to act as the trigger necessary for electron transfer and catalytic activity. (Marletta, Biochemistry, 1997;36:12337-12345). | | 2 | dephosporyl | NOS
Pathway No. 90 | 13.9
(s^-1) | 0
(s^-1) | - | - | Substrate:
NOS*
Products:
nNOS
| | kf -13.9 These rates used to keep the basal level of nNOS at reasonable experimental levels. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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