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Molecule Parameter List for IP4(1456)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP4(1456) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	0	1	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP4(1456) acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP4(1456)	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	1	1000	No
Inositol(1456)tetrakisphosphate

IP4(1456) acting as a Substrate for an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP4-3K  / ip4-3k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.399999	4.3	4	explicit E-S complex	Substrate IP4(1456) Product IP5(13456)
from Stephens et al, Biochem J 249; 1988

IP4(1456) acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
ip4-6pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.01 (s^-1)	0 (s^-1)	-	-	Substrate IP4(1456) Product IP3(145)
this step is essential to maintain flux around the network, rate adjusted accordingly

IP4(1456) acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	ip4(1456)_trp	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	1 (s^-1)	0.001 (s^-1)	Not applicable**	-	Substrate IP4(1456)_ER Product IP4(1456)
	Ins(1456)P4 ER-cytosol transport
2	ip5_3pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.0005 (s^-1)	0 (s^-1)	-	-	Substrate IP5(13456) Product IP4(1456)
	Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991