NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for IP5(13456)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP5(13456) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002273

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 23Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP5(13456) acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP5(13456)
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    53.99921000No
    Inositol(13456)pentakisphosphate Conc from Voglmaier et al, PNAS 93; 1996

    IP5(13456) acting as a Substrate for an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP6_K2  /
    ip5_k2
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    8.40.05724explicit E-S complexSubstrate
    IP5(13456)

    Product
    PP-IP4
        from Saiardi et al, JBC 275(32); 2000: 24686-92
    2IP6-K  /
    ip5_k1
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    6.699990.2344explicit E-S complexSubstrate
    IP5(13456)

    Product
    PP-IP4
        from Saiardi et al, JBC 275(32); 2000: 24686-92

    IP5(13456) acting as a Product of an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP4-1K  /
    ip4-1k
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    0.3599950.5984explicit E-S complexSubstrate
    IP4(3456)

    Product
    IP5(13456)
        from Tan et al, JBC 272; 1997
    2IP4-3K  /
    ip4-3k
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    0.3999994.34explicit E-S complexSubstrate
    IP4(1456)

    Product
    IP5(13456)
        from Stephens et al, Biochem J 249; 1988

    IP5(13456) acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1IP5-inhib-5pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • 145_dephos
    Pathway No. : 114
    1
    (uM^-1 s^-1)
    45
    (s^-1)
    Kd(bf) = 44.9991(uM)-Substrate
    IP5(13456)
    IP_5pase1

    Product
    IP5-5pase-cmplx
      from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
    2ip5_3pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    0.0005
    (s^-1)
    0
    (s^-1)
    --Substrate
    IP5(13456)

    Product
    IP4(1456)
      Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991
    3ip5-1-pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    0.0031
    (s^-1)
    0
    (s^-1)
    --Substrate
    IP5(13456)

    Product
    IP4(3456)
      most probable reaction for Ins(3456)P4 synthesis as per Yang et al, JBC 274(27); 1999: 18973-80
    4ip5-inhib-1k
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    1
    (uM^-1 s^-1)
    15
    (s^-1)
    Kd(bf) = 15(uM)-Substrate
    IP4-1K
    IP5(13456)

    Product
    IP5-1Kcmplx
      from Tan et al, JBC 272; 1997
    5ip5-kinase-pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    1
    (s^-1)
    1.92
    (s^-1)
    Keq = 1.92(uM)0.342secSubstrate
    IP5(13456)

    Product
    IP6
      Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels
    6IP5-dipp-inhib
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    1
    (uM^-1 s^-1)
    1.6
    (s^-1)
    Kd(bf) = 1.6(uM)-Substrate
    DIPP1
    IP5(13456)

    Product
    IP5-DIPPcmplx
      IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998
    7IP5-inhib-3pase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • 1345_dephos
    Pathway No. : 117
    1
    (uM^-1 s^-1)
    0.06
    (s^-1)
    Kd(bf) = 0.06(uM)-Substrate
    1345_3pase
    IP5(13456)

    Product
    IP5-3pase-cmplx
      from Hoer and Oberdisse, Biochem J 278; 1991: 219-224

    IP5(13456) acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1ip5(13456)_trp
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • MIPP
    Pathway No. : 105
    1
    (s^-1)
    0.001
    (s^-1)
    Not applicable**-Substrate
    IP5(13456)_ER

    Product
    IP5(13456)
      Ins(13456)P5 ER-cytosol transport
    2ip4-5K
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    0.008
    (s^-1)
    0
    (s^-1)
    --Substrate
    IP4(1346)

    Product
    IP5(13456)
      rate based on basal levels of Ins(1346)P4
    3dipp_ip6
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    0
    (s^-1)
    0
    (s^-1)
    --Substrate
    PP-IP4

    Product
    IP5(13456)
      rate based on basal levels of PP-InsP4



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.