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Molecule Parameter List for PP-IP4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PP-IP4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002210

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 23Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    PP-IP4 acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    PP-IP4
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    14.99991000No
    Diphosphoinositol tetrakisphosphate Conc from Saiardi et al, JBC 275; 2000

    PP-IP4 acting as a Substrate for an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP6_K2  /
    pp-ip4-k2
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    30.00030.014explicit E-S complexSubstrate
    PP-IP4

    Product
    bisPP-IP3
        from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants
    2IP6-K  /
    pp-ip4-k1
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    23.00030.054explicit E-S complexSubstrate
    PP-IP4

    Product
    bisPP-IP3
        from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants

    PP-IP4 acting as a Product of an Enzyme in  
    NonOsc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP6_K2  /
    ip5_k2
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    8.40.05724explicit E-S complexSubstrate
    IP5(13456)

    Product
    PP-IP4
        from Saiardi et al, JBC 275(32); 2000: 24686-92
    2IP6-K  /
    ip5_k1
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    6.699990.2344explicit E-S complexSubstrate
    IP5(13456)

    Product
    PP-IP4
        from Saiardi et al, JBC 275(32); 2000: 24686-92

    PP-IP4 acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    dipp_ip6
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IHP-system
    Pathway No. : 116
    0
    (s^-1)
    0
    (s^-1)
    --Substrate
    PP-IP4

    Product
    IP5(13456)
    rate based on basal levels of PP-InsP4



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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