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Molecule Parameter List for IP3-56K | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP3-56K acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP3-56K | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 1.632 | 1000 | No | | Ins(134)P3 5,6-kinase from Wilson and Majerus, JBC 271(20); 1996: 11904-10 Reaction products Ins(1346)P4 and Ins(1345)P4 are generated in a ratio of 2.3-5 : 1 |
IP3-56K acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | IP3-Kcmplx-on | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 3
(uM^-1 s^-1) | 0.192
(s^-1) | Kd(bf) = 0.064(uM) | - | Substrate
IP3(134)
IP3-56K
Product
IP3-56Kcmplx
| | Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from Km and Vmax values provided by Wilson and Majerus, JBC 271; 1996 |
IP3-56K acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | 6kinase | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.048
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
IP3-56Kcmplx
Product
IP3-56K
IP4(1346)
| | | Kf = Vmax for IP3 56K from Wilson and Majerus, JBC 271; 1996 | | 2 | 5kinase | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.0132
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
IP3-56Kcmplx
Product
IP3-56K
IP4(1345)
| | | Kf = 0.274 times Vmax of IP3 56-K as product ratio of Ins(1345)P4 : Ins(1346)P4 is 1 : 2.3-5 from Wilson and Majerus, JBC 271; 1996 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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