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Molecule Parameter List for IP3(134)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3(134) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002130

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP3(134) acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3(134)
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 134_dephos
    Pathway No. : 127
    01000No
    Inositol (134)trisphosphate

    IP3(134) acting as a Substrate for an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP_4pase  /
    ip3_4pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 134_dephos
    Pathway No. : 127
    20.0014204explicit E-S complexSubstrate
    IP3(134)

    Product
    IP2(13)
        Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2
    2IP_1pase  /
    ip3_1pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 145_dephos
    Pathway No. : 128
    20.00214.1254explicit E-S complexSubstrate
    IP3(134)

    Product
    IP2(34)
        Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987

    IP3(134) acting as a Product of an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP_5pase1  /
    ip4_5pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 145_dephos
    Pathway No. : 128
    0.800030.094explicit E-S complexSubstrate
    IP4(1345)

    Product
    IP3(134)
    Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3

    IP3(134) acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1IP3-Kcmplx-on
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • IP4-system
    Pathway No. : 129
    3
    (uM^-1 s^-1)
    0.192
    (s^-1)
    Kd(bf) = 0.064(uM)-Substrate
    IP3(134)
    IP3-56K

    Product
    IP3-56Kcmplx
      Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from Km and Vmax values provided by Wilson and Majerus, JBC 271; 1996
    2ip3-inhib-1k
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • IP4-system
    Pathway No. : 129
    1
    (uM^-1 s^-1)
    0.2
    (s^-1)
    Kd(bf) = 0.2(uM)-Substrate
    IP3(134)
    IP4-1K

    Product
    IP3-1Kcmplx
      from Tan et al, JBC 272; 1997
    3134-inhib-3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    1
    (uM^-1 s^-1)
    2
    (s^-1)
    Kd(bf) = 2(uM)-Substrate
    1345_3pase
    IP3(134)

    Product
  • IP3(134)-3pase-c
    mplx

  •   from Hoer et al, Biochem J 270; 1990



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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