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Molecule Parameter List for 1345_3pase

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
1345_3pase participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010050

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    1345_3pase acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    1345_3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    0.11000No
    from Hoer et al, BiochemJ 270; 1990: 715-719

    1345_3pase acting as an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1345_3pase /
    ip4_3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    0.4000070.00124explicit E-S complexSubstrate
    IP4(1345)

    Product
    IP3(145)
    Ins(1345)P4 3-phosphatase from Nogimori et al, JBC 266; 1991

    1345_3pase acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1IP5-inhib-3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    1
    (uM^-1 s^-1)
    0.06
    (s^-1)
    Kd(bf) = 0.06(uM)-Substrate
    1345_3pase
    IP5(13456)

    Product
    IP5-3pase-cmplx
      from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
    2IP6-inhib-3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    1
    (uM^-1 s^-1)
    0.003
    (s^-1)
    Kd(bf) = 0.003(uM)-Substrate
    1345_3pase
    IP6

    Product
  • IP6-inhib-3pase-
    cmplx

  •   from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
    3145-inhib-3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    1
    (uM^-1 s^-1)
    1.75
    (s^-1)
    Kd(bf) = 1.75(uM)-Substrate
    1345_3pase
    IP3(145)

    Product
  • IP3(145)-3pase-c
    mplx

  •   from Hoer et al, Biochem J 270; 1990
    4IP4-inhib-3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    1
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.5(uM)-Substrate
    1345_3pase
    IP4(3456)

    Product
    IP4-3pase-cmplx
      from Hoer et al, Biochem J 270; 1990
    5134-inhib-3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    1
    (uM^-1 s^-1)
    2
    (s^-1)
    Kd(bf) = 2(uM)-Substrate
    1345_3pase
    IP3(134)

    Product
  • IP3(134)-3pase-c
    mplx

  •   from Hoer et al, Biochem J 270; 1990



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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