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Molecule Parameter List for IP4(3456)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP4(3456) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001021

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP4(3456) acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP4(3456)
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • IP4-system
    Pathway No. : 129
    1.41000No
    Inositol (3456)tetrakisphosphate basal levels ~ 1.4uM

    IP4(3456) acting as a Substrate for an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP4-1K  /
    ip4-1k
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • IP4-system
    Pathway No. : 129
    0.3599950.5984explicit E-S complexSubstrate
    IP4(3456)

    Product
    IP5(13456)
    from Tan et al, JBC 272; 1997

    IP4(3456) acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1ip4-inhib-56k
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • IP4-system
    Pathway No. : 129
    1
    (uM^-1 s^-1)
    0.2
    (s^-1)
    Kd(bf) = 0.2(uM)-Substrate
    IP3-56Kcmplx
    IP4(3456)

    Product
  • IP4(3456)-56k-cm
    plx

  •   from Hughes et al, JBC 264(33); 1989: 19871-78
    2IP4-inhib-3pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 1345_dephos
    Pathway No. : 131
    1
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.5(uM)-Substrate
    1345_3pase
    IP4(3456)

    Product
    IP4-3pase-cmplx
      from Hoer et al, Biochem J 270; 1990

    IP4(3456) acting as a Product in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    ip5-1-pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • IP4-system
    Pathway No. : 129
    0.0031
    (s^-1)
    0
    (s^-1)
    --Substrate
    IP5(13456)

    Product
    IP4(3456)
    most probable reaction for Ins(3456)P4 synthesis as per Yang et al, JBC 274(27); 1999: 18973-80



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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