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Molecule Parameter List for IP5(13456) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP5(13456) acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP5(13456) | Osc_Ca_
IP3metabolism
Accession No. : 24 | IHP-system
Pathway No. : 130 | 53.9992 | 1000 | No | | Inositol(13456)pentakisphosphate Conc from Voglmaier et al, PNAS 93; 1996 |
IP5(13456) acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP6_K2 /
ip5_k2 | Osc_Ca_
IP3metabolism
Accession No. : 24 | IHP-system
Pathway No. : 130 | 8.4 | 0.0572 | 4 | explicit E-S complex | Substrate
IP5(13456)
Product
PP-IP4
| | | from Saiardi et al, JBC 275(32); 2000: 24686-92 | | 2 | IP6-K /
ip5_k1 | Osc_Ca_
IP3metabolism
Accession No. : 24 | IHP-system
Pathway No. : 130 | 6.69999 | 0.234 | 4 | explicit E-S complex | Substrate
IP5(13456)
Product
PP-IP4
| | | from Saiardi et al, JBC 275(32); 2000: 24686-92 |
IP5(13456) acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP4-1K /
ip4-1k | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.359995 | 0.598 | 4 | explicit E-S complex | Substrate
IP4(3456)
Product
IP5(13456)
| | | from Tan et al, JBC 272; 1997 | | 2 | IP4-3K /
ip4-3k | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.399999 | 4.3 | 4 | explicit E-S complex | Substrate
IP4(1456)
Product
IP5(13456)
| | | from Stephens et al, Biochem J 249; 1988 |
IP5(13456) acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | ip5-kinase-pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | IHP-system
Pathway No. : 130 | 1
(s^-1) | 1.92
(s^-1) | Keq = 1.92(uM) | 0.342sec | Substrate
IP5(13456)
Product
IP6
| | | Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels | | 2 | IP5-dipp-inhib | Osc_Ca_
IP3metabolism
Accession No. : 24 | IHP-system
Pathway No. : 130 | 1
(uM^-1 s^-1) | 1.6
(s^-1) | Kd(bf) = 1.6(uM) | - | Substrate
DIPP1
IP5(13456)
Product
IP5-DIPPcmplx
| | | IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998 | | 3 | IP5-inhib-5pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | 145_dephos
Pathway No. : 128 | 1
(uM^-1 s^-1) | 45
(s^-1) | Kd(bf) = 44.9991(uM) | - | Substrate
IP5(13456)
IP_5pase1
Product
IP5-5pase-cmplx
| | | from Hoer and Oberdisse, Biochem J 278; 1991: 219-224 | | 4 | ip5_3pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.0005
(s^-1) | 0
(s^-1) | - | - | Substrate
IP5(13456)
Product
IP4(1456)
| | | Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991 | | 5 | ip5-1-pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.0031
(s^-1) | 0
(s^-1) | - | - | Substrate
IP5(13456)
Product
IP4(3456)
| | | most probable reaction for Ins(3456)P4 synthesis as per Yang et al, JBC 274(27); 1999: 18973-80 | | 6 | ip5-inhib-1k | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 1
(uM^-1 s^-1) | 15
(s^-1) | Kd(bf) = 15(uM) | - | Substrate
IP4-1K
IP5(13456)
Product
IP5-1Kcmplx
| | | from Tan et al, JBC 272; 1997 | | 7 | IP5-inhib-3pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | 1345_dephos
Pathway No. : 131 | 1
(uM^-1 s^-1) | 0.06
(s^-1) | Kd(bf) = 0.06(uM) | - | Substrate
1345_3pase
IP5(13456)
Product
IP5-3pase-cmplx
| | | from Hoer and Oberdisse, Biochem J 278; 1991: 219-224 |
IP5(13456) acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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