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Molecule Parameter List for PKA-inhibitor | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| PKA-inhibitor participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Accession and Pathway Details | |
PKA-inhibitor acting as a Molecule in cAMP_pathway Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PKA-inhibitor | cAMP_pathway
Accession No. : 25 | PKA
Pathway No. : 135 | 0.25 | 1000 | No | | About 25% of PKA C subunit is dissociated in resting cells without having any noticable activity. Doskeland and Ogreid Int J biochem 13 pp1-19 suggest that this is because there is a corresponding amount of inhibitor protein. |
PKA-inhibitor acting as a Substrate in a reaction in cAMP_pathway Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | inhib-PKA | cAMP_pathway
Accession No. : 25 | PKA
Pathway No. : 135 | 60
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
PKA-active
PKA-inhibitor
Product
inhibited-PKA
| | This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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