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Molecule Parameter List for GDP.Ga

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*GDP.Ga* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
cAMP_pathway	25	Network	Shared_Object_cAMP_pathway, PKA, AC, Gs
This is a model of the canonical cAMP signaling pathway: Ligand->Receptor->G-protein->Cyclase->cAMP->PKA. It also includes phosphodiesterases to balance out cAMP formation.Bhalla US Methods Enzymol. 2002;345:3-23

GDP.Ga acting as a Molecule in cAMP_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
GDP.Ga	cAMP_pathway Accession No. : 25	Gs Pathway No. : 137	0	1000	No
The inactive GDP-bound form of Gs alpha.

GDP.Ga acting as a Substrate in a reaction in cAMP_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Trimerize-Gs	cAMP_pathway Accession No. : 25	Gs Pathway No. : 137	6 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate GDP.Ga Gbg Product GDP.Gabc
Negligible back-reaction.

GDP.Ga acting as a Product in a reaction in cAMP_pathway Network

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
GTPase	cAMP_pathway Accession No. : 25	Gs Pathway No. : 137	0.0667 (s^-1)	0 (s^-1)	-	-	Substrate GTP.Ga Product GDP.Ga
From Brandt and Ross JBC 261(4):1656-1664, rate is 4/min and is agonist independent. I treat this as irreversible.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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