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Molecule Parameter List for inactiveRas-MKKK | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| inactiveRas-MKKK participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Accession and Pathway Details | |
inactiveRas-MKKK acting as a Molecule in MAPK_osc Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | inactiveRas-MKKK | MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 0 | 0.0016667 | No | | This is the inactive form of Ras-MKKK. Based on the reaction scheme from Kholodenko 2000, this is equivalent to a binding of the MAPK-PP to the Ras. The amount of Ras in the model is small enough that negligible amounts of MAPK are involved in this reaction. So it is a fair approximation to the negative feedback mechanism from Kholodenko, 2000. |
inactiveRas-MKKK acting as a Product in a reaction in MAPK_osc Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | Neg_feedback | MAPK_osc
Accession No. : 27 | MAPK
Pathway No. : 139 | 1
(uM^-1 s^-1) | 0.009
(s^-1) | Kd(bf) = 0.009(uM) | - | Substrate
MAPK-PP
Ras-MKKKK
Product
inactiveRas-MKKK
| | From Kholodenko, 2000 Eur J Biochem 267 the Kd is 9 nM. We use a rather fast Kf of 1/sec/uM so that equilibrium is maintained. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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