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Molecule Parameter List for G*GTP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
G*GTP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000032

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse,  PKC,  PLA2,  
PLCbeta,  Gq,  MAPK,  
Ras,  CaMKII,  CaM,  
PP1,  PP2B,  PKA,  
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

G*GTP acting as a Molecule in  fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
G*GTPfig4_synapse
Accession No. : 3
  • Shared_Object_
    fig4_synapse
    Pathway No. : 19
    		• 01000No

    G*GTP acting as a Substrate in a reaction in      fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Act-PLC-by-Gqfig4_synapse
    Accession No. : 3    		PLCbeta
    Pathway No. : 22    		25.2
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.0397(uM)-Substrate
    G*GTP
    PLC-Ca

    Product
    PLC-Ca-Gq
    2PLC-bind-Gqfig4_synapse
    Accession No. : 3    		PLCbeta
    Pathway No. : 22    		2.52
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 0.3968(uM)-Substrate
    G*GTP
    PLC

    Product
    PLC-Gq
    3Inact-Gfig4_synapse
    Accession No. : 3    		Gq
    Pathway No. : 23    		0.0133
    (s^-1)    		0
    (s^-1)    		--Substrate
    G*GTP

    Product
    G*GDP

    G*GTP acting as a Product in a reaction in      fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Basal-Act-Gfig4_synapse
    Accession No. : 3    		Gq
    Pathway No. : 23    		0.0001
    (s^-1)    		0
    (uM^-1 s^-1)    		--Substrate
    G-GDP

    Product
    BetaGamma
    G*GTP
    2Activate-Gqfig4_synapse
    Accession No. : 3    		Gq
    Pathway No. : 23    		0.01
    (s^-1)    		0
    (uM^-2 s^-1)    		--Substrate
    Rec-Glu-Gq

    Product
    BetaGamma
    G*GTP
    Rec-Glu


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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