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Molecule Parameter List for CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaMKII* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	2	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig4_synapse	3	Network	Shared_Object_fig4_synapse, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, CaMKII, CaM, PP1, PP2B, PKA, AC
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here.

CaMKII acting as a Molecule in fig4_synapse Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII	fig4_synapse Accession No. : 3	CaMKII Pathway No. : 26	70	1000	No

CaMKII acting as a Product of an Enzyme in fig4_synapse Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active / Deph-thr306	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	5.09907	0.35	4	explicit E-S complex	Substrate CaMK-thr306 Product CaMKII
2	PP1-active / Deph_thr286b	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	5.09907	0.35	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII

CaMKII acting as a Substrate in a reaction in fig4_synapse Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaMKII-bind-CaM	fig4_synapse Accession No. : 3	CaMKII Pathway No. : 26	49.9998 (uM^-1 s^-1)	5 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate CaM-Ca4 CaMKII Product CaMKII-CaM
2	basal-activity	fig4_synapse Accession No. : 3	CaMKII Pathway No. : 26	0.003 (s^-1)	0 (s^-1)	-	-	Substrate CaMKII Product CaMKII-thr286

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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