DOQCS database

NCBS Home page

Accession List

Pathway List

Authorized Users

Help

News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Molecule Parameter List for neurogranin*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

neurogranin* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	2	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig4_synapse	3	Network	Shared_Object_fig4_synapse, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, CaMKII, CaM, PP1, PP2B, PKA, AC
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here.

neurogranin* acting as a Molecule in fig4_synapse Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
neurogranin*	fig4_synapse Accession No. : 3	CaM Pathway No. : 27	0	1000	No

neurogranin* acting as a Substrate for an Enzyme in fig4_synapse Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
CaM(Ca)n-CaNAB / dephosph_ neurogranin	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	10.012	0.67	3.98507	explicit E-S complex	Substrate neurogranin* Product neurogranin

neurogranin* acting as a Product of an Enzyme in fig4_synapse Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PKC-active / PKC-phosph-neuro granin	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	28.6275	0.58	4.03448	explicit E-S complex	Substrate neurogranin Product neurogranin*
2	PKC-active / PKC-phosph-ng-Ca M	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	28.5948	0.35	4	explicit E-S complex	Substrate neurogranin-CaM Product CaM neurogranin*

neurogranin* acting as a Substrate in a reaction in fig4_synapse Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dephosph-neurogr anin	fig4_synapse Accession No. : 3	CaM Pathway No. : 27	0.005 (s^-1)	0 (s^-1)	-	-	Substrate neurogranin* Product neurogranin

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.