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Molecule Parameter List for cAMP-PDE* | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| cAMP-PDE* participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| fig4_synapse | 3 | Network | Shared_Object_fig4_synapse, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, CaMKII, CaM, PP1, PP2B, PKA, AC |
| This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here. | |||
cAMP-PDE* acting as a Molecule in fig4_synapse Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| cAMP-PDE* | fig4_synapse Accession No. : 3 | AC Pathway No. : 31 | 0 | 1000 | No | |
cAMP-PDE* acting as an Enzyme in fig4_synapse Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| cAMP-PDE* / PDE* | fig4_synapse Accession No. : 3 | AC Pathway No. : 31 | 19.8413 | 20 | 4 | explicit E-S complex | Substrate cAMP Product AMP |
cAMP-PDE* acting as a Product of an Enzyme in fig4_synapse Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PKA-active / phosph-PDE | fig4_synapse Accession No. : 3 | fig4_synapse Pathway No. : 19 | 7.5 | 9 | 4 | explicit E-S complex | Substrate cAMP-PDE Product cAMP-PDE* |
cAMP-PDE* acting as a Substrate in a reaction in fig4_synapse Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| dephosph-PDE | fig4_synapse Accession No. : 3 | AC Pathway No. : 31 | 0.1 (s^-1) | 0 (s^-1) | - | - | Substrate cAMP-PDE* Product cAMP-PDE |