Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Search in:

ALL Accession Pathway Molecule Enzyme Reaction Connected to

Search for

Match

Anything Exact Word Starting With

By

Name Notes Model

Molecule Parameter List for ip1_1pase_cmplx

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

ip1_1pase_cmplx participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	31	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

ip1_1pase_cmplx acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
ip1_1pase_cmplx	NonOsc_Ca_ IP3metabolism Accession No. : 31	134_dephos Pathway No. : 152	0	1000	No
Enzyme complex exclusively modeled to accomodate enzyme reversibility as calculated from dG calculations for -5 kJ/mol.

ip1_1pase_cmplx acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1pase-off	NonOsc_Ca_ IP3metabolism Accession No. : 31	134_dephos Pathway No. : 152	11.43 (s^-1)	0.0008 (uM^-1 s^-1)	Kd(cb) = 0.0001(uM)	-	Substrate ip1_1pase_cmplx Product IP1_pase inositol
Kf = Vmax for Ins(1)P1-1phosphatase: Gee et al, Biochem J 249, 1988. Kb necessary as estimated from percent inositol backflux calculations. This contributes to maintain Ins(1)P1 at 10% of its actual pool.

ip1_1pase_cmplx acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1pase-on	NonOsc_Ca_ IP3metabolism Accession No. : 31	134_dephos Pathway No. : 152	0.3572 (uM^-1 s^-1)	45.72 (s^-1)	Kd(bf) = 128.0005(uM)	-	Substrate IP1(1) IP1_pase Product ip1_1pase_cmplx
Rates derived from Km for Ins(1)P1-1phosphatase: Gee et al, Biochem J 249; 1988.