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Molecule Parameter List for IP_5pase1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*IP_5pase1* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	2	0	0	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	31	Network	MIPP, CaMKII, CaM, PKC, IP3-3K, CaRegulation, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP_5pase1 acting as a Molecule in NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP_5pase1	NonOsc_Ca_ IP3metabolism Accession No. : 31	145_dephos Pathway No. : 153	12.346	1000	No
from Hansen et al, JBC 262(36); Dec 25 1987: 17319-26 InsP 5phosphatase1 has two 5-phosphatase activities: against Ins(145)P3 and Ins(1345)P4 respectively

IP_5pase1 acting as an Enzyme in NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP_5pase1 / ip3_5pase1	NonOsc_Ca_ IP3metabolism Accession No. : 31	145_dephos Pathway No. : 153	3.00001	1.1	4	explicit E-S complex	Substrate IP3(145) Product IP2(14)
	Ins(145)P3 5-phosphatase activity of InsP-5-phosphatase from Hansen et al, JBC 262; 1987
2	IP_5pase1 / ip4_5pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	145_dephos Pathway No. : 153	0.80003	0.09	4	explicit E-S complex	Substrate IP4(1345) Product IP3(134)
	Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3

IP_5pase1 acting as a Substrate in a reaction in NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	IP5-inhib-5pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	145_dephos Pathway No. : 153	1 (uM^-1 s^-1)	45 (s^-1)	Kd(bf) = 44.9991(uM)	-	Substrate IP5(13456) IP_5pase1 Product IP5-5pase-cmplx
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
2	IP6-inhib-5pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	145_dephos Pathway No. : 153	1 (uM^-1 s^-1)	16 (s^-1)	Kd(bf) = 15.9997(uM)	-	Substrate IP6 IP_5pase1 Product IP6-5pase-inhib
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224

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