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Molecule Parameter List for IP_1pase | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP_1pase acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP_1pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | 145_dephos
Pathway No. : 166 | 5.0163 | 1000 | No | | from Inhorn and Majerus; JBC 262(33), 1987 pp 15946-15952 InsP-1-phosphatase has two enzyme activities against Ins(14)P2 and Ins(134)P3 respectively |
IP_1pase acting as an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP_1pase /
ip2_1pase
| Osc_Ca_
IP3metabolism
Accession No. : 32 | 145_dephos
Pathway No. : 166 | 5.00005 | 2 | 4 | explicit E-S complex | Substrate
IP2(14)
Product
IP1(4)
| | | from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14) | | 2 | IP_1pase /
ip3_1pase
| Osc_Ca_
IP3metabolism
Accession No. : 32 | 145_dephos
Pathway No. : 166 | 20.0021 | 4.125 | 4 | explicit E-S complex | Substrate
IP3(134)
Product
IP2(34)
| | | Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987 |
IP_1pase acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | Ca-inhib-1pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | 145_dephos
Pathway No. : 166 | 1
(uM^-1 s^-1) | 6
(s^-1) | Kd(bf) = 5.9999(uM) | - | Substrate
Ca
IP_1pase
Product
Ca-1pase-cmplx
| | Ki from Inhorn & Majerus, BiochemJ 262(33); 1987: 15946-52 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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