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Molecule Parameter List for IP1(4)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP1(4) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000110

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 32Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP1(4) acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP1(4)
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 145_dephos
    Pathway No. : 166
    01000No
    Inositol 4-monophosphate Basal levels = 10% of Ins(1)P1 ~ 4uM Ackermann et al, BiochemJ 242, 1987(2): 517

    IP1(4) acting as a Product of an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP_1pase  /
    ip2_1pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 145_dephos
    Pathway No. : 166
    5.0000524explicit E-S complexSubstrate
    IP2(14)

    Product
    IP1(4)
    from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)

    IP1(4) acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    4pase-on
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 145_dephos
    Pathway No. : 166
    1.035
    (uM^-1 s^-1)
    157.32
    (s^-1)
    Kd(bf) = 152(uM)-Substrate
    IP1(4)
    IP1_pase

    Product
    ip1_4pase_cmplx
    Rates derived from Ins(4)P1 4-phosphatase Km: Gee et al, Biochem J 249; 1988



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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