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Molecule Parameter List for IP4(1346) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP4(1346) acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP4(1346) | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP4-system
Pathway No. : 167 | 1 | 1000 | No | | Inositol (1346)tetrakisphosphate |
IP4(1346) acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | ip4-5K | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP4-system
Pathway No. : 167 | 0.15
(s^-1) | 0.003
(s^-1) | Keq = 0.02(uM) | 6.536sec | Substrate
IP4(1346)
Product
IP5(13456)
| | Kf based on basal levels of Ins(1346)P4 Kb obtained from dG calculations for equilibrium product substrate conditions. |
IP4(1346) acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 6kinase | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP4-system
Pathway No. : 167 | 0.256
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
IP3-56Kcmplx
Product
IP3-56K_IP4-1K
IP4(1346)
| | Kf = Vmax for IP3 56-K from Yang and Shears, Biochem J 2000; 351:551-555 Enzyme reversibility reported in Ho et al, Curr Biol 2002, 12: 1-20. But backflow calculations do not show that Kb needs to be incorporated |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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