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Molecule Parameter List for IP3(134) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP3(134) acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP3(134) | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP4-system
Pathway No. : 167 | 0 | 1000 | No | | Inositol (134)trisphosphate |
IP3(134) acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP_4pase /
ip3_4pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 20.0014 | 20 | 4 | explicit E-S complex | Substrate
IP3(134)
Product
IP2(13)
| | | Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2 | | 2 | IP_1pase /
ip3_1pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | 145_dephos
Pathway No. : 166 | 20.0021 | 4.125 | 4 | explicit E-S complex | Substrate
IP3(134)
Product
IP2(34)
| | | Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987 |
IP3(134) acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP_5pase1 /
ip4_5pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | 145_dephos
Pathway No. : 166 | 0.80003 | 0.09 | 4 | explicit E-S complex | Substrate
IP4(1345)
Product
IP3(134)
| | Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3 |
IP3(134) acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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