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Molecule Parameter List for IP_5pase1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP_5pase1 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1020020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 32Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP_5pase1 acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP_5pase1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 145_dephos
    Pathway No. : 166
    12.3461000No
    from Hansen et al, JBC 262(36); Dec 25 1987: 17319-26 InsP 5phosphatase1 has two 5-phosphatase activities: against Ins(145)P3 and Ins(1345)P4 respectively

    IP_5pase1 acting as an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP_5pase1 /
    ip3_5pase1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 145_dephos
    Pathway No. : 166
    3.000011.14explicit E-S complexSubstrate
    IP3(145)

    Product
    IP2(14)
        Ins(145)P3 5-phosphatase activity of InsP-5-phosphatase from Hansen et al, JBC 262; 1987
    2IP_5pase1 /
    ip4_5pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 145_dephos
    Pathway No. : 166
    0.800030.094explicit E-S complexSubstrate
    IP4(1345)

    Product
    IP3(134)
        Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3

    IP_5pase1 acting as a Substrate in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1IP5-inhib-5pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 145_dephos
    Pathway No. : 166
    1
    (uM^-1 s^-1)
    45
    (s^-1)
    Kd(bf) = 44.9991(uM)-Substrate
    IP5(13456)
    IP_5pase1

    Product
    IP5-5pase-cmplx
      from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
    2IP6-inhib-5pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 32
  • 145_dephos
    Pathway No. : 166
    1
    (uM^-1 s^-1)
    16
    (s^-1)
    Kd(bf) = 15.9997(uM)-Substrate
    IP6
    IP_5pase1

    Product
    IP6-5pase-inhib
      from Hoer and Oberdisse, Biochem J 278; 1991: 219-224



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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