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Molecule Parameter List for DIPP1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*DIPP1* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	2	0	0	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	32	Network	MIPP, CaMKII, CaM, PKC, IP3-3K, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos, CaRegulation, Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

DIPP1 acting as a Molecule in Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
DIPP1	Osc_Ca_ IP3metabolism Accession No. : 32	IHP-system Pathway No. : 168	0.1267	1000	No
Diphosphoinositol-Polyphosphate Phosphohydrolase from Safrany et al, EMBO J 17(22); 1998: 6599-607

DIPP1 acting as an Enzyme in Osc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	DIPP1 / dipp_ip8	Osc_Ca_ IP3metabolism Accession No. : 32	IHP-system Pathway No. : 168	0.0340035	0.6165	4	explicit E-S complex	Substrate bisPP-IP4 Product PP-IP5
	from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of human recombinant protein, which is 20-50 fold greater than activity of the purified rat enzyme
2	DIPP1 / dipp_ip7	Osc_Ca_ IP3metabolism Accession No. : 32	IHP-system Pathway No. : 168	0.340006	5.1	4	explicit E-S complex	Substrate PP-IP5 Product IP6
	from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of recombinant human protein which is 20-50 fold greater than activity of the purified rat enzyme

DIPP1 acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	IP5-dipp-inhib	Osc_Ca_ IP3metabolism Accession No. : 32	IHP-system Pathway No. : 168	1 (uM^-1 s^-1)	1.6 (s^-1)	Kd(bf) = 1.6(uM)	-	Substrate DIPP1 IP5(13456) Product IP5-DIPPcmplx
	IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998
2	IP6-dipp-inhib	Osc_Ca_ IP3metabolism Accession No. : 32	IHP-system Pathway No. : 168	1 (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate DIPP1 IP6 Product IP6-DIPPcmplx
	IC50=0.2uM from Safrany et al, EMBO J 17(22); 1998

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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