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Molecule Parameter List for A2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

A2 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
MAPK_Asthagiri_ adapt_fb	45	Pathway	MAPK
This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

A2 acting as a Molecule in MAPK_Asthagiri_adapt_fb Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
A2	MAPK_Asthagiri_ adapt_fb Accession No. : 45	MAPK Pathway No. : 193	0.0427	390	No
Second adaptor protein. Tot.no. 10^4 no./cell from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

A2 acting as a Substrate in a reaction in MAPK_Asthagiri_adapt_fb Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	C*A1-bind-A2	MAPK_Asthagiri_ adapt_fb Accession No. : 45	MAPK Pathway No. : 193	5.0001 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate A2 CA1 Product* E0*
	kf2 and kr2 are 310^8 M-1 min-1 and 0.5/sec from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39*
2	A1-bind-A2	MAPK_Asthagiri_ adapt_fb Accession No. : 45	MAPK Pathway No. : 193	5.0001 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate A1 A2 Product A1A2
	Kc12 and Kd12 are 310^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger 2001.*

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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