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Molecule Parameter List for P1 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| P1 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | MAPK_Asthagiri_
enz_fb | 46 | Pathway |
MAPK_Asthagiri_enz_fb | This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of enzyme targeted negative feedback mechanism in generating downstream signal adaptation. This model simulates the results as per the simulation conditions specified for figure 7B of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.
However, there is some discrepancy with the outputs shown in Figure 7B. |
P1 acting as a Molecule in MAPK_Asthagiri_enz_fb Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | P1 | MAPK_Asthagiri_
enz_fb
Accession No. : 46 | MAPK_Asthagiri_
enz_fb
Pathway No. : 194 | 0.0214 | 390 | No | | Deactivating enzyme, P1^T = 5000 no./cell from Asthagiri and Lauffenburger, 2001 |
P1 acting as an Enzyme in MAPK_Asthagiri_enz_fb Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | P1 /
E1*_deactiv
| MAPK_Asthagiri_
enz_fb
Accession No. : 46 | MAPK_Asthagiri_
enz_fb
Pathway No. : 194 | 0.0600001 | 0.1 | 5 | explicit E-S complex | Substrate
E1*
Product
E1
| | kp1+ =6*10^8 M-1 min-1, kp1- =30 min-1, kpcat,1 =6 min-1 form Asthagiri and Lauffenburger 2001. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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