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Molecule Parameter List for PKC-DAG-memb*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

PKC-DAG-memb* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
PKC_2003	48	Pathway	PKC_2003, PKC
This model consists of receptor-ligand interaction, G-protein activation, Adenylyl cyclase mediated formation of cAMP and activation of PKA in the neuron. Demonstration programs using this model described in Bhalla US. (2004) Biophys J. 87(2):733-44 to generate a dose-response curve using stochastic calculations are available here.

PKC-DAG-memb* acting as a Molecule in PKC_2003 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKC-DAG-memb*	PKC_2003 Accession No. : 48	PKC Pathway No. : 200	0	1000	No

PKC-DAG-memb* acting as a Summed Molecule in PKC_2003 Network

Accession Name	Pathway Name	Target	Input
PKC_2003 Accession No. : 48	PKC_2003 Pathway No. : 199	PKC-active	PKC-DAG-AA* PKC-Ca-memb* PKC-Ca-AA* PKC-DAG-memb* PKC-basal* PKC-AA*
Conc of PKC in brain is about 1 uM (?)

PKC-DAG-memb* acting as a Product in a reaction in PKC_2003 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PKC-DAG-to-memb	PKC_2003 Accession No. : 48	PKC Pathway No. : 200	1 (s^-1)	0.1 (s^-1)	Keq = 0.1(uM)	0.909sec	Substrate PKC-Ca-DAG Product PKC-DAG-memb*
Raise kb from .087 to 0.1 to match data from Shinomura et al. Lower kf from 1.155 to 1.0 to match data from Shinomura et al.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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