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Molecule Parameter List for CaMK-thr306

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMK-thr306 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
CaMKII_200349Network
Shared_Object_CaMKII_2003,  CaMKII,  CaM,  
PP1,  PP2B 
Model of regulation of CaMKII by Calcium, including parallel excitatory input from CaM and inhibitory input from PP1 as regulated by Calcineurin and PKA. Cell type: neuronal.
Bhalla US. Biophys J. 2004 Aug;87(2):733-44.

CaMK-thr306 acting as a Molecule in  CaMKII_2003 Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
CaMK-thr306CaMKII_2003
Accession No. : 49		CaMKII
Pathway No. : 202		01000No
This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992

CaMK-thr306 acting as a Substrate for an Enzyme in  CaMKII_2003 Network
Enzyme Molecule /
Enzyme Activity		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
PP1-active  /
Deph-thr306		CaMKII_2003
Accession No. : 49
  • Shared_Object_
    CaMKII_2003
    Pathway No. : 201
    		• 5.099070.354explicit E-S complexSubstrate
    CaMK-thr306

    Product
    CaMKII
    See Cohen et al

    CaMK-thr306 acting as a Product of an Enzyme in      CaMKII_2003 Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PP1-active  /
    Deph-thr286c    		CaMKII_2003
    Accession No. : 49
  • Shared_Object_
    CaMKII_2003
    Pathway No. : 201
    		• 5.099070.354explicit E-S complexSubstrate
    CaMKII***

    Product
    CaMK-thr306


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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