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Molecule Parameter List for CaNAB-Ca4 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
CaNAB-Ca4 acting as a Molecule in CaMKII_2003 Network
CaNAB-Ca4 acting as an Enzyme in CaMKII_2003 Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | CaNAB-Ca4 /
dephosph_
inhib1_noCaM
| CaMKII_2003
Accession No. : 49 | Shared_Object_
CaMKII_2003
Pathway No. : 201 | 4.97076 | 0.034 | 4 | explicit E-S complex | Substrate
I1*
Product
I1
| | The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034 |
CaNAB-Ca4 acting as a Substrate in a reaction in CaMKII_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | CaM-Ca2-bind-CaN
AB | CaMKII_2003
Accession No. : 49 | PP2B
Pathway No. : 205 | 0.24
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 4.1667(uM) | - | Substrate
CaM-TR2-Ca2
CaNAB-Ca4
Product
CaMCa2-CANAB
| | | Disabled. See notes for PP2B7.g | | 2 | CaMCa3-bind-CaNA
B | CaMKII_2003
Accession No. : 49 | PP2B
Pathway No. : 205 | 2.238
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.4468(uM) | - | Substrate
CaM-Ca3
CaNAB-Ca4
Product
CaMCa3-CaNAB
| | 3 | CaMCa4-bind-CaNA
B | CaMKII_2003
Accession No. : 49 | PP2B
Pathway No. : 205 | 600
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.0017(uM) | - | Substrate
CaM-Ca4
CaNAB-Ca4
Product
CaMCa4-CaNAB
|
CaNAB-Ca4 acting as a Product in a reaction in CaMKII_2003 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | Ca-bind-CaNAB-Ca
2 | CaMKII_2003
Accession No. : 49 | PP2B
Pathway No. : 205 | 3.6
(uM^-2 s^-1) | 1
(s^-1) | Kd(af) = 0.527(uM) | - | Substrate
Ca
Ca
CaNAB-Ca2
Product
CaNAB-Ca4
| | This process is probably much more complicated and involves CaM. However, as I can't find detailed info I am bundling this into a single step. Based on Steemer and Klee pg 6863, the Kact is 0.5 uM. kf/kb = 1/(0.5 * 6e5)^2 = 1.11e-11 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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