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Molecule Parameter List for PIP2-PLA2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

PIP2-PLA2* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
MAPK_network_ 2003	50	Network	Shared_Object_MAPK_network_2003, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, EGFR, Sos, PLC_g, CaMKII, CaM, PP1, PP2B, PKA, AC
This is a network model of many pathways present at the neuronal synapse. The network has properties of temporal tuning as well as steady-state computational properties. In its default form the network is bistable.Bhalla US Biophys J. 2004 Aug;87(2):745-53

PIP2-PLA2* acting as a Molecule in MAPK_network_2003 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PIP2-PLA2*	MAPK_network_ 2003 Accession No. : 50	PLA2 Pathway No. : 208	0	1000	No

PIP2-PLA2* acting as an Enzyme in MAPK_network_2003 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PIP2-PLA2* / kenz	MAPK_network_ 2003 Accession No. : 50	PLA2 Pathway No. : 208	20	11.04	4	explicit E-S complex	Substrate APC Product AA
10 X raise oct 22 12 X further raise oct 24 to allow for correct conc of enzyme

PIP2-PLA2* acting as a Product in a reaction in MAPK_network_2003 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PIP2-PLA2-act	MAPK_network_ 2003 Accession No. : 50	PLA2 Pathway No. : 208	0.0012 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 416.6667(uM)	-	Substrate PLA2-cytosolic temp-PIP2 Product PIP2-PLA2*

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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