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Molecule Parameter List for Shc*.Sos.Grb2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Shc*.Sos.Grb2 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| EGFR_MAPK | 58 | Network | Shared_Object_EGFR_MAPK, MAPK, Ras, EGFR, Sos |
| Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here. Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53. | |||
Shc*.Sos.Grb2 acting as a Molecule in EGFR_MAPK Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| Shc*.Sos.Grb2 | EGFR_MAPK Accession No. : 58 | EGFR_MAPK Pathway No. : 229 | 0 | 1000 | No | |
Shc*.Sos.Grb2 acting as an Enzyme in EGFR_MAPK Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| Shc*.Sos.Grb2 / Sos.Ras_GEF | EGFR_MAPK Accession No. : 58 | EGFR_MAPK Pathway No. : 229 | 0.505051 | 0.02 | 4 | explicit E-S complex | Substrate GDP-Ras Product GTP-Ras |
Shc*.Sos.Grb2 acting as a Product in a reaction in EGFR_MAPK Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
Sos.Grb2 | EGFR_MAPK Accession No. : 58 | Sos Pathway No. : 233 | 0.5 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.2(uM) | - | Substrate SHC* Sos.Grb2 Product Shc*.Sos.Grb2 |
| Sasaoka et al JBC 269:51 pp 32621 1994, table on pg 32623 indicates that this pathway accounts for about 50% of the GEF activation. (88% - 39%). Error is large, about 20%. Fig 1 is most useful in constraining rates. Chook et al JBC 271:48 pp 30472, 1996 say that the Kd is 0.2 uM for Shc binding to EGFR. The Kd for Grb direct binding is 0.7, so we'll ignore it. | |||||||